The second stage of syphilis representing dissemination of the Treponema pallidum spirochete from the primary site of inoculation. This stage may overlap with primary syphilis and is typically characterized by hallmark generalized lesions; often involves constitutional symptoms, such as malaise, fever, swollen lymph glands, etc. For more information, visit: http://www.cdc.gov/std/syphilis/stdfact-syphilis.htm